DiffusionMeeting10May200792013-03-07 21:22:57localhostconverted to 1.6 markup82007-05-10 19:48:46SoniaBishop72007-05-10 16:38:42devel06.mrc-cbu.cam.ac.uk62007-05-10 16:36:33devel06.mrc-cbu.cam.ac.uk52007-05-10 16:35:01devel06.mrc-cbu.cam.ac.uk42007-05-10 16:34:40devel06.mrc-cbu.cam.ac.uk32007-05-10 16:34:26devel06.mrc-cbu.cam.ac.uk22007-05-10 16:34:02devel06.mrc-cbu.cam.ac.uk12007-05-10 16:10:35pc0179.mrc-cbu.cam.ac.ukNotes from informal meeting about diffusionOn 10 May 2007 Acquisition issuesNeed for optimization for fibre trackingIssues are: Number of averages vs number of directions Isotropic vs defined diffusion angles - relating to anatomy Cardiac gating; expected differences; whether this can be easily applied using Siemens setup. Is currently working for Oxford with Siemens patches - these may not be available to us CBU acquisitionsDefault is 63 angles, 2 averages, 14 minutes Alternative 30 directions 3 or 4 averages Need to investigate which is preferable for fibre tracking WBICFor fibre tracking: 8 minutes, 2mm isotropic, 63 directions - ? one average (as it were) For traumatic brain injury patients (Virginia Newcombe): 12 direction, 5 B values (allowing more accurate estimation of diffusion coefficent) Physicists involved are Guy Williams + Adrian Carpenter AnalysisCBU currently using FSL - see DiffusionFdtNotes BrainVisa set up, but display not working due to OpenGL problems. Needs local (desktop) install WBIC using dtiquery - good display routines, fibre tracking - algorithm? Have also used FSL - particularly for fibre track cross subject analysis using TBSS program (see below). Open questionsHow to do quantitative cross-subject analysis or fibre track anatomy in relationship to neuropsychology? Investigation of TBSS? Using FSL fibre tracking for statistical analysis across subjects of connectivity between areas PlanHope to set up more knowledge sharing between WBIC and CBU / CSL. Maybe Wiki pages for WBIC on diffusion experience and software. First step at understanding cross-subject analyses? Suggest journal club on TBSS main paper. S.M. Smith, H. Johansen-Berg, M. Jenkinson, D. Rueckert, T.E. Nichols, K.L. Miller, M.D. Robson, D.K. Jones, J.C. Klein, A.J. Bartsch, and T.E.J. Behrens. Acquisition and voxelwise analysis of multi-subject diffusion data with Tract-Based Spatial Statistics. Nature Protocols, 2(3):499-503, 2007. Technical report: MatthewBrett